Detre S I, Gazet J C
Br J Cancer. 1973 Nov;28(5):412-6. doi: 10.1038/bjc.1973.166.
Five out of 18 primary explants of human carcinomata obtained at operation have been grown progressively for a minimum of one month in thymectomized, x-irradiated mice reconstituted with syngeneic bone marrow and subsequently treated also with anti-thymocyte serum. All the tumours which proliferated were of gastrointestinal origin, growing locally but not metastasizing although direct invasion of the ribs occurred in one case. No implanted breast carcinomata grew in this system.
在手术中获取的18个原发性人类癌组织外植体中，有5个在经胸腺切除、X射线照射、用同基因骨髓重建且随后还用抗胸腺细胞血清处理的小鼠体内持续生长了至少1个月。所有增殖的肿瘤均起源于胃肠道，虽有1例发生了对肋骨的直接侵犯，但肿瘤仅在局部生长，未发生转移。在该系统中，植入的乳腺癌组织均未生长。
