头孢蚜霉菌产生的一种新型抗生素——阿非科林的抗病毒作用
Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola.
作者信息
Bucknall R A, Moores H, Simms R, Hesp B
出版信息
Antimicrob Agents Chemother. 1973 Sep;4(3):294-8. doi: 10.1128/AAC.4.3.294.
Abstract
Aphidicolin is an antibiotic of novel structure produced by the mold Cephalosporium aphidicola. It is a potent inhibitor of cellular deoxyribonucleic acid synthesis, and it also strongly inhibits the growth of herpes simplex virus both in tissue culture and in the rabbit eye. Aphidicolin is active against iododeoxyuridine-resistant herpes virus, and does not itself readily induce the formation of drug-resistant strains of herpesvirus.
摘要
阿非科林是由霉菌蚜虫头孢菌产生的一种新结构抗生素。它是细胞脱氧核糖核酸合成的有效抑制剂，在组织培养和兔眼中也能强烈抑制单纯疱疹病毒的生长。阿非科林对碘脱氧尿苷耐药的疱疹病毒有活性，其本身不容易诱导产生疱疹病毒耐药菌株。
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Incorporation of iododeoxyuridine into the deoxyribonucleic acid of mouse Ehrlich-ascites-tumor cells in vivo.碘脱氧尿苷在体内掺入小鼠艾氏腹水瘤细胞的脱氧核糖核酸中。
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