脊髓灰质炎病毒的形态发生。II. 一种新中间体——前病毒体的证明。
Morphogenesis of poliovirus. II. Demonstration of a new intermediate, the proviron.
作者信息
Fernandez-Tomas C B, Baltimore D
出版信息
J Virol. 1973 Nov;12(5):1122-30. doi: 10.1128/JVI.12.5.1122-1130.1973.
Abstract
Poliovirus-infected cells contain a previously unrecognized particle which appears to be an intermediate in virion synthesis and therefore has been named proviron. It sediments at about 125S, contains the three procapsid proteins, VP-0, VP-1, and VP-3, and has 35S viral RNA. It is disrupted both by sodium dodecyl sulfate and EDTA but the RNA resists digestion by ribonuclease. Pulsechase experiments and studies employing the virus-specific inhibitor, guanidine, all indicate that the proviron is formed by combination of newly made RNA with the procapsid. Cleavage of VP-0 to form VP-2 and VP-4 follows formation of the provirion and would be the final step in poliovirus morphogenesis.
摘要
感染脊髓灰质炎病毒的细胞含有一种以前未被识别的颗粒，它似乎是病毒体合成的中间体，因此被命名为前病毒体。它在约125S处沉降，含有三种前衣壳蛋白VP-0、VP-1和VP-3，并含有35S病毒RNA。它能被十二烷基硫酸钠和乙二胺四乙酸破坏，但RNA能抵抗核糖核酸酶的消化。脉冲追踪实验以及使用病毒特异性抑制剂胍的研究均表明，前病毒体是由新合成的RNA与前衣壳结合形成的。VP-0裂解形成VP-2和VP-4发生在前病毒体形成之后，这将是脊髓灰质炎病毒形态发生的最后一步。
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