英国酒精性肝病研究。I. 与自然史相关的临床和病理模式
Studies in alcoholic liver disease in Britain. I. Clinical and pathological patterns related to natural history.
作者信息
Brunt P W, Kew M C, Scheuer P J, Sherlock S
出版信息
Gut. 1974 Jan;15(1):52-8. doi: 10.1136/gut.15.1.52.
Abstract
A group of 258 patients with various forms of alcoholic liver disease-steatosis, mild and severe hepatitis, and cirrhosis-has been studied. Severity of disease as judged histologically did not correlate very well with clinical presentation although signs of hepatocellular failure were certainly commoner in severe hepatitis and cirrhosis. Fever, pigmentation, and clubbing were also pointers to these two conditions. Alcoholic hepatitis is probably precirrhotic and carries a poor prognosis and the best laboratory indicators of this are moderate elevation of white cell count and bilirubin. Prognosis in alcoholic liver disease is significantly improved by abstinence from alcohol.
摘要
对一组258例患有各种形式酒精性肝病（脂肪变性、轻度和重度肝炎以及肝硬化）的患者进行了研究。尽管肝细胞衰竭的体征在重度肝炎和肝硬化中肯定更为常见，但组织学判断的疾病严重程度与临床表现的相关性并不是很好。发热、色素沉着和杵状指也是这两种情况的指征。酒精性肝炎可能处于肝硬化前期，预后较差，对此最好的实验室指标是白细胞计数和胆红素中度升高。戒酒可显著改善酒精性肝病的预后。
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本文引用的文献
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