Assmann G, Brewer H B
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1534-8. doi: 10.1073/pnas.71.4.1534.
Based on the analysis of recombined lipidapoprotein complexes by C-13 and P-31 nuclear magnetic resonance spectroscopy and circular dichroism [Assmann, G., Sokoloski, E. A. & Brewer, H. B., Jr. (1974) Proc. Nat. Acad. Sci. USA 71, 549-553; Assmann, G., Highet, R. J., Sokoloski, E. A. & Brewer, H. B., Jr. (1974) Proc. Nat. Acad. Sci. USA 71, in press; Assmann, G. & Brewer, H. B., Jr. (1974) Proc. Nat. Acad. Sci. USA 71, 989-993] and the identification of conformational amphipathic regions in apoproteins, a new model for human high density lipoproteins is proposed. This model is analogous to membrane models proposed by Singer, in that protein "icebergs" are embedded in a "sea" of lipid.
基于通过碳-13和磷-31核磁共振光谱以及圆二色性对重组脂蛋白复合物的分析[阿斯曼,G.,索科洛斯基,E. A.和布鲁尔,H. B.,Jr.(1974年)《美国国家科学院院刊》71,549 - 553;阿斯曼,G.,希格特,R. J.,索科洛斯基,E. A.和布鲁尔,H. B.,Jr.(1974年)《美国国家科学院院刊》71,即将发表;阿斯曼,G.和布鲁尔,H. B.,Jr.(1974年)《美国国家科学院院刊》71,989 - 993]以及对载脂蛋白中构象两性区域的鉴定,提出了一种人类高密度脂蛋白的新模型。该模型类似于辛格提出的膜模型,即蛋白质“冰山”嵌入脂质“海洋”中。