Kirsten肉瘤病毒大鼠基因序列的特征：内源性大鼠C型病毒序列的独特类别
Characterizatiion of rat genetic sequences of Kirsten sarcoma virus: distinct class of endogenous rat type C viral sequences.
作者信息
Scolnick E M, Goldberg R J, Williams D
出版信息
J Virol. 1976 May;18(2):559-66. doi: 10.1128/JVI.18.2.559-566.1976.
Abstract
The nucleic acid sequences found in DNA and RNA from rat cells which are homologous to Kirsten sarcoma virus have been characterized. The homologous sequences are present in multiple copies per diploid rat cellular genome in a variety of different rat cellular dna's. In certain cells that constitutively express only low levels of sequences homologous to Kirsten sarcoma virus, bromodeoxyuridine treatment leads to the expression of high levels of these sequences in RNA. Supernatants from cell lines producing the sequences homologous to Kirsten sarcoma virus contain high levels of these sequences which are purified to the same degree as the previously known rat type C viral nucleic acid sequences by type C particles being released from such cells. The results indicate that the sequences in rat cells homologous to Kisten sarcoma virus have three characteristics of known mammalian type C viruses, and suggest that at least part of Kirsten sarcoma virus rat-derived sequences represent a distinct class of endogenous rat type C virus that has no detectable homology to the other known class of endogenous rat type C virus.
摘要
已对大鼠细胞DNA和RNA中与 Kirsten 肉瘤病毒同源的核酸序列进行了表征。这些同源序列以多个拷贝存在于每个二倍体大鼠细胞基因组中，存在于多种不同的大鼠细胞DNA中。在某些仅组成性表达低水平与Kirsten肉瘤病毒同源序列的细胞中，溴脱氧尿苷处理导致这些序列在RNA中高水平表达。产生与Kirsten肉瘤病毒同源序列的细胞系的上清液中含有高水平的这些序列，这些序列通过从这些细胞中释放C型颗粒而被纯化到与先前已知的大鼠C型病毒核酸序列相同的程度。结果表明，大鼠细胞中与Kisten肉瘤病毒同源的序列具有已知哺乳动物C型病毒的三个特征，并表明Kirsten肉瘤病毒大鼠来源的序列至少部分代表了一类独特的内源性大鼠C型病毒，与另一类已知的内源性大鼠C型病毒没有可检测到的同源性。
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