在鼠细胞中鉴定出一种具有缺陷型C型病毒特性的30S RNA。
Identification of a 30S RNA with properties of a defective type C virus in murine cells.
作者信息
Howk R S, Troxler D H, Lowy D, Duesberg P H, Scolnick E M
出版信息
J Virol. 1978 Jan;25(1):115-23. doi: 10.1128/JVI.25.1.115-123.1978.
Abstract
A novel species of 30S RNA has been detected in a variety of mouse cell lines. The 30S RNA is specifically packaged by helper-independent type C viruses propagated in such cells. Nucleic acid hybridization detects no homology between the 30SRNA and the genomic RNA of helper-independent mouse type C viruses. The properties of the 30S RNA suggest that it is a defective endogenous mouse type C virus and that it is analogous to a previously described class of defective endogenous rat type C virus, which has been shown previously to be the progenitor of Kirsten and Harvey murine sarcoma viruses.
摘要
在多种小鼠细胞系中检测到了一种新型的30S RNA。30S RNA被在此类细胞中增殖的辅助非依赖型C病毒特异性包装。核酸杂交检测显示30S RNA与辅助非依赖型小鼠C型病毒的基因组RNA之间不存在同源性。30S RNA的特性表明它是一种有缺陷的内源性小鼠C型病毒，并且类似于先前描述的一类有缺陷的内源性大鼠C型病毒，后者先前已被证明是 Kirsten 和 Harvey 小鼠肉瘤病毒的前身。
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