梅毒螺旋体对氧的摄取
Oxygen uptake by Treponema pallidum.
作者信息
Cox C D, Barber M K
出版信息
Infect Immun. 1974 Jul;10(1):123-7. doi: 10.1128/iai.10.1.123-127.1974.
Abstract
Virulent Treponema pallidum has been shown to consume O(2) at a rate similar to that of the known aerobic spirochaete, Leptospira. Such O(2) uptake is cyanide sensitive, indicating a functioning cytochrome oxidase. Inhibition of O(2) uptake by azide, chlorpromazine, and amytal further suggests a functioning electron transport system for the oxidation of nicotinamide adenine dinucleotide (reduced) to O(2). Evidence is consistent with the probability that this terminal electron-transport system is coupled to oxidative phosphorylation. The potential significance of these findings is discussed.
摘要
毒力梅毒螺旋体已被证明消耗氧气的速率与已知的需氧螺旋体钩端螺旋体相似。这种氧气摄取对氰化物敏感，表明细胞色素氧化酶功能正常。叠氮化物、氯丙嗪和戊巴比妥对氧气摄取的抑制进一步表明存在一个将烟酰胺腺嘌呤二核苷酸（还原型）氧化为氧气的正常运转的电子传递系统。有证据支持这一最终电子传递系统与氧化磷酸化相偶联的可能性。本文讨论了这些发现的潜在意义。
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