口蹄疫病毒毒株的补体结合试验研究。I. 抗原 - 抗体混合物补体结合的模型
A study of foot-and-mouth disease virus strains by complement fixation. I. A model for the fixation of complement by antigen-antibody mixtures.
作者信息
Forman A J
出版信息
J Hyg (Lond). 1974 Jun;72(3):397-405. doi: 10.1017/s0022172400023639.
Abstract
An examination was made of the relations between antigen, antibody and fixation of complement with foot-and-mouth disease virus (FMDV). It was found that complement fixation in this system follows the same principles as models developed in other antigen/antibody systems. The assumption that there is a relation of direct proportionality between the amount of complement fixed and the amount of antiserum reacting with constant antigen was found to be incorrect. An alternative method was proposed for the quantitative differentiation of FMDV strains by comparing the titres of an antiserum when reacting with optimum amounts of homologous or heterologous antigens.
摘要
对口蹄疫病毒（FMDV）的抗原、抗体及补体结合之间的关系进行了研究。结果发现，该系统中的补体结合遵循与其他抗原/抗体系统中建立的模型相同的原理。发现补体结合量与恒定抗原反应的抗血清量之间存在正比关系这一假设是不正确的。提出了一种通过比较抗血清与最佳量的同源或异源抗原反应时的效价来定量区分FMDV毒株的替代方法。
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A study of foot-and-mouth disease virus strains by complement fixation. I. A model for the fixation of complement by antigen-antibody mixtures.口蹄疫病毒毒株的补体结合试验研究。I. 抗原 - 抗体混合物补体结合的模型
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A study of foot-and-mouth disease virus strains by complement fixation. II. A comparison of tube and microplate tests for the differentiation of strains.口蹄疫病毒毒株的补体结合试验研究。II. 用于毒株鉴别的试管试验与微量板试验的比较
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本文引用的文献
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Principles governing the practical application of complement-fixation tests.
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A COMPLEMENT FIXATION TECHNIQUE FOR THE QUANTITATIVE MEASUREMENT OF ANTIGENIC DIFFERENCES BETWEEN STRAINS OF THE VIRUS OF FOOT-AND-MOUTH DISEASE.一种用于定量测定口蹄疫病毒毒株间抗原差异的补体结合技术。
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PURIFICATION OF RADIOACTIVE FOOT-AND-MOUTH DISEASE VIRUS.放射性口蹄疫病毒的纯化
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J Exp Med. 1958 May 1;107(5):665-90. doi: 10.1084/jem.107.5.665.
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