Carsiotis M, Jones R F, Lacy A M, Cleary T J, Fankhauser D B
J Bacteriol. 1970 Oct;104(1):98-106. doi: 10.1128/jb.104.1.98-106.1970.
The formation of the five tryptophan biosynthetic enzymes of Neurospora crassa was shown to be derepressed in histidine-starved cells. This histidine-mediated derepression was not due to a lowered intracellular concentration of tryptophan in these cells. Furthermore, histidine-mediated derepression of tryptophan enzymes was found to be coordinate and not subject to reversal by tryptophan of either exogenous or biosynthetic origin. The synthesis of tryptophan enzymes also was found to be coordinate in cells which were not histidine-starved. Although histidine is clearly involved in regulating the synthesis of tryptophan enzymes, it did not prevent either tryptophan-mediated derepression of tryptophan enzymes or indole-3-glycerol phosphate-mediated derepression of tryptophan synthetase.
已证明，在组氨酸饥饿的细胞中，粗糙脉孢菌的五种色氨酸生物合成酶的形成会去阻遏。这种组氨酸介导的去阻遏并非由于这些细胞中色氨酸的细胞内浓度降低。此外，发现组氨酸介导的色氨酸酶去阻遏是协同的，并且不受外源或生物合成来源的色氨酸逆转。在未处于组氨酸饥饿状态的细胞中，也发现色氨酸酶的合成是协同的。尽管组氨酸显然参与调节色氨酸酶的合成，但它既没有阻止色氨酸介导的色氨酸酶去阻遏，也没有阻止吲哚 - 3 - 甘油磷酸介导的色氨酸合成酶去阻遏。
