Kapikian A Z
Prev Med. 1974 Dec;3(4):535-42. doi: 10.1016/0091-7435(74)90019-x.
Two virus-like particles have been found to be associated with acute viral gastroenteritis. One, a 270-nm parvovirus-like particle (the Norwalk agent), was visualized and recognized by immune electron microscopy in an infectious stool filtrate derived from a community outbreak of nonbacterial gastroenteritis. It appears to be one of the etiologic agents of a usually self-limited form of gastroenteritis which commonly occurs in community outbreaks. The other, a 70-nm reovirus-like particle, has been observed by electron microscopy in specimens from infants and children with severe diarrhea in many parts of the world. The reovirus-like particle may emerge as a major etiologic agent of diarrhea of infants and young children.
已发现两种病毒样颗粒与急性病毒性肠胃炎有关。一种是270纳米的细小病毒样颗粒（诺沃克因子），在一次社区非细菌性肠胃炎暴发所产生的传染性粪便滤液中，通过免疫电子显微镜观察到并识别出了这种颗粒。它似乎是通常呈自限性的一种肠胃炎的病原体之一，这种肠胃炎常见于社区暴发。另一种是70纳米的呼肠孤病毒样颗粒，在世界许多地区患有严重腹泻的婴幼儿标本中，通过电子显微镜观察到了这种颗粒。呼肠孤病毒样颗粒可能会成为婴幼儿腹泻的一种主要病原体。
