Kapikian A Z, Kim H W, Wyatt R G, Rodriguez W J, Ross S, Cline W L, Parrott R H, Chanock R M
Science. 1974 Sep 20;185(4156):1049-53. doi: 10.1126/science.185.4156.1049.
Reoviruslike particles were visualized by electron microscopy in stool filtrates prepared from stools of infants and young children with severe acute gastroenteritis. Patients who had such particles in their stools and whose paired acute and convalescent serums were tested developed an antibody response to the reoviruslike agent, which was measured by immune electron microscopy and by complement fixation. The reoviruslike agent was antigenically related to the epizootic diarrhea of infant mice virus and the Nebraska calf diarrhea virus.
通过电子显微镜在患有严重急性胃肠炎的婴幼儿粪便滤液中观察到呼肠孤病毒样颗粒。粪便中含有此类颗粒且检测了配对的急性期和恢复期血清的患者，对呼肠孤病毒样病原体产生了抗体反应，这通过免疫电子显微镜和补体结合试验进行测定。该呼肠孤病毒样病原体在抗原性上与幼鼠流行性腹泻病毒和内布拉斯加牛腹泻病毒相关。
