急性颅脑损伤时的局部脑血流量与脑室内压
Regional cerebral blood flow and intraventricular pressure in acute head injuries.
作者信息
Fieschi C, Battistini N, Beduschi A, Boselli L, Rossanda M
出版信息
J Neurol Neurosurg Psychiatry. 1974 Dec;37(12):1378-88. doi: 10.1136/jnnp.37.12.1378.
Abstract
Twelve patients who were comatose after head injuries were studied with serial determinations of regional cerebral blood flow, jugular PO(2) tension, and intraventricular pressure. These determinations began a few hours after the injury, and were followed throughout the clinical course. Diffuse derangement of cerebral vasomotor regulation is confirmed after severe head trauma, which may contribute to deterioration and poor prognosis, and which indicates a need for therapeutic maintenance of rich oxygenation, hyperventilation with moderate hypocapnia, and steady blood pressure. Continuous recording of IVP (eventually sensitized by fluid infusion or CO(2) inhalation tests) may give an early indication of the subsequent clinical state and may suggest the need to submit the patients to further investigative and therapeutic procedures.
摘要
对12例头部受伤后昏迷的患者进行了研究，连续测定局部脑血流量、颈静脉血氧分压和脑室内压。这些测定在受伤后数小时开始，并在整个临床过程中持续进行。严重头部创伤后证实存在脑血管运动调节的弥漫性紊乱，这可能导致病情恶化和预后不良，这表明需要通过维持充足的氧合、适度低碳酸血症的过度通气和稳定的血压进行治疗。持续记录脑室内压（最终通过液体输注或二氧化碳吸入试验使其敏感化）可能会早期提示后续的临床状态，并可能提示需要对患者进行进一步的检查和治疗程序。
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