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新生儿胸腺移植。I. 关于循环胸腺因子（FTS）水平调节的研究。

Neonatal thymus grafts. I. Studies on the regulation of the level of circulating thymic factor (FTS).

作者信息

Tubiana N, Dardenne M

出版信息

Immunology. 1979 Feb;36(2):207-13.

PMID:437830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457481/
Abstract

The level of circulating thymic factor (FTS) tested by its action on spleen rosette-forming cells from adult thymectomized mice, has been shown to be stable in young animals. This stability suggests a regulatory mechanism. An approach of this regulation has been attempted by disrupting the FTS level either by neonatal thymus grafting in adult normal and thymectomized animals, or by injections of synthetic thymic factor into normal, thymectomized mice, grafted or ungrafted. In all cases, after an initial increase over the normal value, FTS levels returned close to the previous range, indicating the existence of some homeostatic mechanism of FTS secretion.

摘要

通过检测循环胸腺因子（FTS）对成年去胸腺小鼠脾细胞玫瑰花结形成细胞的作用发现，该因子在幼龄动物体内水平稳定。这种稳定性提示存在一种调节机制。我们尝试通过以下方式探究这种调节机制：对成年正常和去胸腺动物进行新生期胸腺移植，或对正常、去胸腺的移植或未移植小鼠注射合成胸腺因子，以此扰乱FTS水平。在所有情况下，FTS水平在最初高于正常值后，又恢复至先前范围，这表明存在某种FTS分泌的稳态机制。

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引用本文的文献

1
Thymic hormone containing cells. III. Evidence for a feed-back regulation of the secretion of the serum thymic factor (FTS) by thymic epithelial cells.含胸腺激素细胞。III. 胸腺上皮细胞对血清胸腺因子（FTS）分泌进行反馈调节的证据。
Clin Exp Immunol. 1983 Apr;52(1):7-12.

本文引用的文献

1
THE AUTONOMOUS BEHAVIOUR OF NORMAL THYMUS GRAFTS.正常胸腺移植的自主行为
Aust J Exp Biol Med Sci. 1963 Aug;41:SUPPL437-47. doi: 10.1038/icb.1963.64.
2
Electron microscopic studies of thymus graft regeneration and rejection. I. Syngeneic grafts.胸腺移植再生与排斥反应的电子显微镜研究。I. 同基因移植。
Lab Invest. 1967 Jan;16(1):66-83.
3
Regeneration of thymus grafts. I. Histological and cytological aspects.胸腺移植的再生。I. 组织学和细胞学方面。
Transplantation. 1965 Sep;3(5):639-68. doi: 10.1097/00007890-196509000-00006.
4
Studies on thymus products. II. Demonstration and characterization of a circulating thymic hormone.胸腺产物的研究。II. 一种循环胸腺激素的证明与特性分析。
Immunology. 1973 Sep;25(3):353-66.
5
Studies on thymus products. I. Modification of rosette-forming cells by thymic extracts. Determination of the target RFC sub-population.胸腺产物的研究。I. 胸腺提取物对玫瑰花结形成细胞的修饰。靶玫瑰花结形成细胞亚群的测定。
Immunology. 1973 Sep;25(3):343-52.
6
Studies on thymus products. IV. Absence of serum 'thymic activity' in adult NZB and (NZB x NZW) F1 mice.胸腺产物的研究。IV. 成年NZB和（NZB×NZW）F1小鼠血清中不存在“胸腺活性”
Clin Exp Immunol. 1973 Jun;14(2):247-56.
7
Thymic hormones?胸腺激素？
Ann N Y Acad Sci. 1975 Feb 28;249:61-7. doi: 10.1111/j.1749-6632.1975.tb29058.x.
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Ontogeny of thymus factor secretion.胸腺因子分泌的个体发生。
Ann Immunol (Paris). 1976 Nov-Dec;127(6):963-6.
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Isolation, biochemical characteristics, and biological activity of a circulating thymic hormone in the mouse and in the human.小鼠和人类体内循环胸腺激素的分离、生化特性及生物活性
Ann N Y Acad Sci. 1975 Feb 28;249:186-210. doi: 10.1111/j.1749-6632.1975.tb29068.x.
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Cell Immunol. 1976 Oct;26(2):308-12. doi: 10.1016/0008-8749(76)90374-9.

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