Wing E J, Krahenbuhl J L, Remington J S
Immunology. 1979 Mar;36(3):479-85.
Studies were made to investigate the quantitative and functional changes which occur in peritoneal macrophage populations obtained from mice infected orally with Trichinella spiralis larvae. C57BL/6 mice infected with T. spiralis larvae became parasitized with adult worms which were rejected from the intestine from 14 to 20 days after infection. Infected mice developed a striking increase in peritoneal exudate cells, composed largely of macrophages, which was maximal at from 16 to 18 days after infection. T. spiralis larvae and eosinophils were not seen in the peritoneal exudates. Macrophages from mice infected more than 11 days earlier inhibited DNA synthesis of syngeneic and allogeneic tumour cells, a property atributed to activated macrophages. In addition, macrophages from T. spiralis-infected mice had the functional ability to kill EL-4 tumour cells as measured by 51Cr release. Unlike activated macrophages, however, macrophages from infected mice did not develop the ability to inhibit multiplication of the intracellular pathogen Toxoplasma gondii. These studies demonstrate that T. spiralis infection in mice induces changes in macrophage function that differ from changes associated with infections by intracellular pathogens.
开展了多项研究，以调查从经口感染旋毛虫幼虫的小鼠获取的腹膜巨噬细胞群体中发生的数量和功能变化。感染旋毛虫幼虫的C57BL/6小鼠被成虫寄生，成虫在感染后14至20天从肠道被清除。感染小鼠的腹膜渗出细胞显著增加，主要由巨噬细胞组成，在感染后16至18天达到最大值。在腹膜渗出物中未见到旋毛虫幼虫和嗜酸性粒细胞。感染超过11天的小鼠的巨噬细胞抑制同基因和异基因肿瘤细胞的DNA合成，这一特性归因于活化的巨噬细胞。此外，通过51Cr释放测定，来自感染旋毛虫小鼠的巨噬细胞具有杀死EL-4肿瘤细胞的功能能力。然而，与活化的巨噬细胞不同，来自感染小鼠的巨噬细胞没有产生抑制细胞内病原体弓形虫增殖的能力。这些研究表明，小鼠感染旋毛虫会诱导巨噬细胞功能发生变化，这些变化不同于与细胞内病原体感染相关的变化。
