环状芽孢杆菌产生的一种新型多肽类抗生素——permetin A的结构。

The structure of permetin A, a new polypeptin type antibiotic produced by Bacillus circulans.

作者信息

Takeuchi Y, Murai A, Takahara Y, Kainosho M

出版信息

J Antibiot (Tokyo). 1979 Feb;32(2):121-9. doi: 10.7164/antibiotics.32.121.

DOI:10.7164/antibiotics.32.121

Abstract

The structure of permetin A(I), an antibiotic substance produced by Bacillus circulans AJ 3902, has been elucidated as a cyclic acyl peptide by means of the mass and nuclear magnetic resonance spectroscopic techniques. (Formula: see text.) The structure was found to be the same as polypeptin A(II) except that L-Thr in II is replaced by L-Ser in I. Details of the structural determination are given for the permetin A itself as well as for the hydrolyzed permetin A. (Formula: see text.)

摘要

环状芽孢杆菌AJ 3902产生的抗生素物质Permetin A（I）的结构，已通过质谱和核磁共振光谱技术阐明为环状酰基肽。（化学式：见正文）。发现其结构与多杀菌素A（II）相同，只是II中的L-苏氨酸被I中的L-丝氨酸取代。给出了Permetin A本身以及水解后的Permetin A的结构测定细节。（化学式：见正文）

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