一种与抗生素EM 49相关的新型抗生素333-25的分离。（芽孢杆菌属抗生素研究。XI）

Isolation of a new antibiotic 333-25, related to antibiotic EM 49. (Studies on antibiotics from the genus Bacillus. XI).

作者信息

Shoji J, Hinoo H, Wakisaka Y, Koizumi K, Mayama M

出版信息

J Antibiot (Tokyo). 1976 May;29(5):516-20. doi: 10.7164/antibiotics.29.516.

DOI:10.7164/antibiotics.29.516

Abstract

A new antibiotic, 333-25, active against Gram-positive and Gram-negative bacteria, was isolated from the culture broth of Bacillus circulans 333-25. The antibiotic is a basic acylpeptide containing 2,4-diaminobutyric acid (5), leucine (2), phenylalanine (1) and a fatty acid. It is closely related to antibiotic EM 49, but can be differentiated by chromatographic behaviour.

摘要

一种对革兰氏阳性菌和革兰氏阴性菌均有活性的新型抗生素333 - 25，是从环状芽孢杆菌333 - 25的培养液中分离得到的。该抗生素是一种碱性酰基肽，含有2,4 - 二氨基丁酸（5个）、亮氨酸（2个）、苯丙氨酸（1个）和一种脂肪酸。它与抗生素EM 49密切相关，但可通过色谱行为加以区分。