用于检测风疹病毒抗体的被动血凝和血凝抑制技术的比较。
Comparison of passive haemagglutination and haemagglutination-inhibition techniques for detection of antibodies to rubella virus.
作者信息
Birch C J, Glaun B P, Hunt V, Irving L G, Gust I D
出版信息
J Clin Pathol. 1979 Feb;32(2):128-31. doi: 10.1136/jcp.32.2.128.
Because of the technical problems and length of time involved in the satisfactory performance of the haemagglutination-inhibition test for detection of rubella-specific antibodies, a commercially available passive haemagglutination (PHA) kit utilising rubella antigen-sensitised human erythrocytes was tested for its suitability for use in diagnostic laboratories. The immune response to acute rubella infections as measured by PHA was considerably delayed compared to the response measured by haemagglutination-inhitition. Titres of rubella-specific antibody only became comparable six months after the infection. The commercially available PHA kits is a useful addition to diagnostic laboratories for the determination of immune status and, in conjunction with the haemagglutination-inhibition test, can be an indicator of recent rubella infection.
由于用于检测风疹特异性抗体的血凝抑制试验存在技术问题且耗时较长，因此对一种市售的利用风疹抗原致敏人红细胞的被动血凝（PHA）试剂盒进行了测试，以评估其在诊断实验室中的适用性。与血凝抑制试验所测的免疫反应相比，PHA所测的对急性风疹感染的免疫反应出现了相当大的延迟。风疹特异性抗体滴度在感染后六个月才变得相当。市售的PHA试剂盒是诊断实验室用于确定免疫状态的有用补充，并且与血凝抑制试验结合使用时，可作为近期风疹感染的一个指标。
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