Gikalov I, Bircher J
Eur J Clin Pharmacol. 1977 Nov 14;12(3):229-33. doi: 10.1007/BF00609866.
Although the aminopyrine breath test has received much attention, the question has not yet been settled whether pharmacological or tracer doses of the drug should be used. Nine volunteers were given 14C-aminopyrine 9 mg/kg or a tracer amount, in a randomized sequence and according to a crossover design. The specific activity of 14CO2 in breath was significantly different only during the first hour. Up to the 8th hour the disappearance of 14CO2 from breath was smaller after the pharmacological (28.5 +/- SD 5.4%/h) than after the tracer dose (36.2 +/- 10.6%/h; p less than 0.05). The over-all disappearance of 14C-atoms from the subjects was significantly slower after the higher dose. In view of the smaller radiation exposure and the decreased risk of agranulocytosis, the use of a tracer dose appears preferable.
尽管氨基比林呼气试验备受关注，但药物的药理剂量或示踪剂量该如何使用这一问题尚未得到解决。9名志愿者按照随机顺序和交叉设计，分别给予9毫克/千克的14C-氨基比林或示踪剂量。仅在第一个小时内，呼出气体中14CO2的比活度有显著差异。直至第8小时，药理剂量组（28.5±标准差5.4%/小时）呼出气体中14CO2的消失量小于示踪剂量组（36.2±10.6%/小时；p<0.05）。较高剂量组受试者体内14C原子的总体消失速度明显较慢。鉴于辐射暴露较小且粒细胞缺乏症风险降低，使用示踪剂量似乎更为可取。
