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来自29型肺炎球菌的型特异性物质。

The type-specific substance from Pneumococcus type 29.

作者信息

Rao E V, Watson M J, Buchanan J G, Baddiley J

出版信息

Biochem J. 1969 Feb;111(4):547-56. doi: 10.1042/bj1110547.

Abstract
  1. A pentasaccharide, corresponding to the dephosphorylated repeating unit of the specific substance, S.29, from Pneumococcus type 29, was obtained by hydrolysis with alkali followed by enzymic dephosphorylation. 2. The pentasaccharide was shown to be O-2-acetamido-2-deoxy-beta-d-galactopyranosyl-(1-->6)-O-beta-d-galactofuranosyl-(1-->3)-O-beta-d-galactopyranosyl-(1-->6)-O-beta-d-galactofuranosyl-(1-->1)-ribitol. 3. The phosphodiester linkages in S.29 join the hydroxyl group at position 5 of ribitol and the hydroxyl group at position 3 or 4 of a 2-acetamido-2-deoxy-d-galactose residue in the next repeating unit. 4. A partial structure for S.29 was deduced from these experiments.
摘要
  1. 一种五糖,对应于29型肺炎球菌特异性物质S.29的去磷酸化重复单元,通过碱水解然后酶促去磷酸化获得。2. 该五糖被证明是O-2-乙酰氨基-2-脱氧-β-D-吡喃半乳糖基-(1→6)-O-β-D-呋喃半乳糖基-(1→3)-O-β-D-吡喃半乳糖基-(1→6)-O-β-D-呋喃半乳糖基-(1→1)-核糖醇。3. S.29中的磷酸二酯键连接核糖醇5位的羟基和下一个重复单元中2-乙酰氨基-2-脱氧-D-半乳糖残基3位或4位的羟基。4. 从这些实验中推导出了S.29的部分结构。

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Infect Immun. 1983 Sep;41(3):1234-44. doi: 10.1128/iai.41.3.1234-1244.1983.

本文引用的文献

3
Separation of the phosphoric esters on the filter paper chromatogram.磷酸酯在滤纸色谱上的分离
Nature. 1949 Dec 31;164(4183):1107-12, illust. doi: 10.1038/1641107a0.
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Detection of sugars on paper chromatograms.纸色谱上糖的检测
Nature. 1950 Sep 9;166(4219):444-5. doi: 10.1038/166444b0.
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THE PNEUMOCOCCAL POLYSACCHARIDES.肺炎球菌多糖
Adv Carbohydr Chem. 1964;19:303-58. doi: 10.1016/s0096-5332(08)60285-4.

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