Russell C D, Cash A G
J Nucl Med. 1979 Jun;20(6):532-7.
The reduction of [99Tc]pertechnetate was studied as a function of pH in complexing media of pyrophosphate, methylene diphosphonate (MDP), and ethane-1, hydroxy-1, and 1-diphosphonate (HEDP). Tast (sampled d-c) and normal-pulse polarography were used to study the reduction of pertechnetate, and normal-pulse polarography (sweeping in the anodic direction) to study the reoxidation of the products. Below pH 6 TcO4-was reduced to Tc(III), which could be reoxidized to Tc(IV). Above pH 10, TcO4-was reduced in two steps to Tc(V) and Tc(IV), each of which could be reoxidized to TcO4-. Between pH 6 and 10 the results differed according to the ligand present. In pyrophosphate and MDP, TcO4- was reduced in two steps to Tc(IV) and Tc(III); Tc(III) could be reoxidized in two steps to Tc(IV) and TcO4-. In HEDP, on the other hand, TcO4- was reduced in two steps to Tc(V) and Tc(III), and could be reoxidized to Tc(IV) and TcO4-. Additional waves were observed; they apparently led to unstable products.
研究了在焦磷酸盐、亚甲基二膦酸盐（MDP）和乙烷-1,1-二羟基-1,1-二膦酸盐（HEDP）络合介质中，高锝酸盐[99Tc]的还原与pH值的关系。采用塔斯特（采样d-c）和常规脉冲极谱法研究高锝酸盐的还原，采用常规脉冲极谱法（向阳极方向扫描）研究产物的再氧化。在pH值低于6时，高锝酸盐（TcO4-）被还原为Tc(III)，后者可再氧化为Tc(IV)。在pH值高于10时，高锝酸盐分两步还原为Tc(V)和Tc(IV)，每一步都可再氧化为高锝酸盐。在pH值6至10之间，结果因存在的配体而异。在焦磷酸盐和MDP中，高锝酸盐分两步还原为Tc(IV)和Tc(III)；Tc(III)可分两步再氧化为Tc(IV)和高锝酸盐。另一方面，在HEDP中，高锝酸盐分两步还原为Tc(V)和Tc(III)，并可再氧化为Tc(IV)和高锝酸盐。观察到了额外的波；它们显然导致了不稳定的产物。
