Mar P
J Neurol Sci. 1980 Aug;47(2):285-303. doi: 10.1016/0022-510x(80)90012-x.
The blood serum of patients with multiple sclerosis (MS) was capable of recruiting autologous as well as normal mononuclear leucocytes in specific antibody-dependent cellular cytotoxicity (ADCC) of rat glial tumor CCL 107/C6 cells. The gliotoxic ADCC activity of MS patients was significantly higher than that of normal persons and patients with other neurological diseases. MS serum alone or in combination with guinea pig complement was not cytotoxic for glial targets, and MS leucocytes alone displayed only nonspecific natural killer (NK) cell activity, which did not differ from that of normal persons. MS ADCC activity was tissue-specific for glial cells, being almost negligible for embryonic human lung fibroblasts and nonspecific for HeLa cells. Gliotoxic ADCC activity was higher in more severely disabled MS patients than in those who were less disabled. Patients with chronic progressive MS displayed the most significantly raised ADCC activity against glial cells, while patients in a stationary state had almost normal ADCC activity.
在大鼠胶质细胞瘤CCL 107/C6细胞的特异性抗体依赖性细胞毒性（ADCC）中，多发性硬化症（MS）患者的血清能够募集自体以及正常的单核白细胞。MS患者的神经胶质毒性ADCC活性显著高于正常人和其他神经系统疾病患者。单独的MS血清或与豚鼠补体联合使用对神经胶质靶细胞没有细胞毒性，单独的MS白细胞仅表现出非特异性自然杀伤（NK）细胞活性，这与正常人的活性没有差异。MS的ADCC活性对神经胶质细胞具有组织特异性，对人胚胎肺成纤维细胞几乎可以忽略不计，对HeLa细胞则无特异性。在残疾程度较重的MS患者中，神经胶质毒性ADCC活性高于残疾程度较轻的患者。慢性进行性MS患者对神经胶质细胞的ADCC活性升高最为显著，而处于静止期的患者ADCC活性几乎正常。
