肺炎球菌中的不稳定二元包膜转化体。
Unstable binary capsulated transformants in pneumococcus.
作者信息
Bernheimer H P, Wermundsen I E
出版信息
J Bacteriol. 1969 Jun;98(3):1073-9. doi: 10.1128/jb.98.3.1073-1079.1969.
Abstract
Through transformation reactions, binary capsulated SI-III strains of pneumococci have been isolated that are unstable and lose the SI capsular genome at high frequency. The instability is caused by the specific mutation in the SIII capsular genome common to all of the unstable strains. In the family of strains studied, the SI capsular genome was integrated into the recipient chromosome in at least two loci: one apparently adjacent to the resident capsular genome and a second some distance from it. A hypothesis is presented to explain the instability of the strains on the basis of redundancy of genetic information.
摘要
通过转化反应，已分离出二元包囊化的肺炎球菌SI-III菌株，这些菌株不稳定，且高频丢失SI荚膜基因组。这种不稳定性是由所有不稳定菌株共有的SIII荚膜基因组中的特定突变引起的。在所研究的菌株家族中，SI荚膜基因组至少在两个位点整合到受体染色体中：一个位点显然与常驻荚膜基因组相邻，另一个位点则与之相距一段距离。本文提出了一个基于遗传信息冗余来解释这些菌株不稳定性的假说。
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本文引用的文献
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