对细菌感染的天然免疫：补体与热不稳定调理素的关系。
Natural immunity to bacterial infections: the relation of complement to heat-labile opsonins.
作者信息
Smith M R, Shin H S, Wood W B
出版信息
Proc Natl Acad Sci U S A. 1969 Aug;63(4):1151-6. doi: 10.1073/pnas.63.4.1151.
Abstract
Heat-labile opsonins to pneumococci in normal mammalian sera, unlike antibodies, fail to interact with the bacteria at 0 degrees C and require Ca(++) and/or Mg(++). They are readily removed from serum by antigen-antibody complexes that fix complement (C) and are inhibited by reagents that inactivate various C components. The principal heat-labile opsonin to pneumococci is activated C3 (C3(b)), but a slight enhancing effect is exerted by one or more of the late-reacting components of the hemolytic complement system (C5-C9). Since heat-labile opsonins are immunologically polyspecific, they presumably play a broad protective role in the early (preantibody) phase of acute bacterial infections.
摘要
与抗体不同，正常哺乳动物血清中针对肺炎球菌的热不稳定调理素在0摄氏度时无法与细菌相互作用，并且需要钙离子（Ca(++)）和/或镁离子（Mg(++)）。它们很容易被固定补体（C）的抗原-抗体复合物从血清中去除，并被使各种补体成分失活的试剂所抑制。针对肺炎球菌的主要热不稳定调理素是活化的C3（C3(b)），但溶血补体系统的一种或多种后期反应成分（C5-C9）会产生轻微的增强作用。由于热不稳定调理素在免疫上具有多特异性，它们可能在急性细菌感染的早期（抗体前）阶段发挥广泛的保护作用。
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