D-苯丙胺使脑5-羟色胺的周转率增加。
Turnover rate of brain 5-hydroxytryptamine increased by D-amphetamine.
作者信息
Reid W D
出版信息
Br J Pharmacol. 1970 Nov;40(3):483-91. doi: 10.1111/j.1476-5381.1970.tb10629.x.
Abstract
- Administration of two doses of amphetamine HCl (5 mg/kg intraperitoneally) 45 min apart raised body temperature of rats by an average of 3.4 degrees C and increased the turnover rate of brain 5-hydroxytryptamine (5-HT) by almost one-half.2. Both effects were blocked by exposure to 4 degrees C or by pretreatment with the beta-blocker Kö 592 (1-(2-methylphenoxy)-3-isopropylamine-2-propanol), but not by the administration of the ganglionic blocker chlorisondamine combined with atropine.3. Since it has previously been shown that hyperthermia per se increases the turnover rate of brain 5-HT, and that amphetamine does not directly affect the uptake and release of 5-HT in brain slices, it is concluded that the amphetamine-induced increase in 5-HT turnover may be secondary to the rise in temperature produced by the drug.
摘要
间隔45分钟腹腔注射两剂盐酸苯丙胺（5毫克/千克）使大鼠体温平均升高3.4摄氏度，并使脑5-羟色胺（5-HT）的周转率提高近一半。
暴露于4摄氏度或用β受体阻滞剂Kö 592（1-(2-甲基苯氧基)-3-异丙胺-2-丙醇）预处理均可阻断这两种效应，但给予神经节阻滞剂氯异吲哚铵与阿托品联合使用则不能阻断。
由于先前已表明体温过高本身会增加脑5-HT的周转率，且苯丙胺不会直接影响脑切片中5-HT的摄取和释放，因此得出结论，苯丙胺诱导的5-HT周转率增加可能继发于该药物引起的体温升高。
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本文引用的文献
1
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Proc Natl Acad Sci U S A. 1961 May;47(5):730-9. doi: 10.1073/pnas.47.5.730.
2
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Br J Pharmacol Chemother. 1965 Jun;24(3):759-72. doi: 10.1111/j.1476-5381.1965.tb01632.x.
3
MICRODETERMINATION OF MONOAMINE OXIDASE AND 5-HYDROXYTRYPTOPHAN DECARBOXYLASE ACTIVITIES IN NERVOUS TISSUES.神经组织中单胺氧化酶和5-羟色氨酸脱羧酶活性的微量测定
J Neurochem. 1965 Jan;12:15-23. doi: 10.1111/j.1471-4159.1965.tb10246.x.
4
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J Pharmacol Exp Ther. 1964 Sep;145:344-50.
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