Pettingale K W, Merrett T G, Tee D E
Br J Cancer. 1977 Nov;36(5):550-7. doi: 10.1038/bjc.1977.230.
One hundred and sixty women admitted for breast tumour biopsy to the King's College Hospital group have been followed sequentially for 2 years. Sixty-nine women had early operable breast cancer and 91 had benign breast disease. All these women had serum immunoglobulin IgG, IgA, IgM and IgE levels measured preoperatively and postoperatively at 3 months, 1 year and 2 years. No differences were found in any of the serum immunoglobulin levels between the two groups at any time. There was, however, a positive correlation between the extent of metastatic breast cancer and the serum level of various immunoglobulins, particularly IgA. There was no evidence that routine postoperative radiotherapy influenced the levels of serum immunoglobulins. The findings suggest a secondary defence reaction against increasing tumour load, and do not support the theory of an early immune defect in immunoglobulin metabolism which could play a part in the pathogenesis of breast cancer. Although there is no diagnostic value in measuring the levels of serum immunoglobulins in patients with breast tumours, there may be some value in following the levels in cancer patients, as a guide to subclinical spread of the disease.
对160名因乳腺肿瘤活检而入住国王学院医院组的女性进行了连续2年的随访。69名女性患有早期可手术乳腺癌，91名患有良性乳腺疾病。所有这些女性在术前以及术后3个月、1年和2年时均检测了血清免疫球蛋白IgG、IgA、IgM和IgE水平。两组在任何时间的任何血清免疫球蛋白水平上均未发现差异。然而，转移性乳腺癌的程度与各种免疫球蛋白的血清水平之间存在正相关，尤其是IgA。没有证据表明常规术后放疗会影响血清免疫球蛋白水平。这些发现提示了针对肿瘤负荷增加的次级防御反应，并不支持免疫球蛋白代谢早期免疫缺陷理论，该理论可能在乳腺癌发病机制中起作用。虽然测量乳腺肿瘤患者的血清免疫球蛋白水平没有诊断价值，但在癌症患者中跟踪这些水平可能有一定价值，可作为疾病亚临床扩散的指导。
