急性前葡萄膜炎中的HLA - B27频率及混合淋巴细胞反应

HLA-B27 frequency and MLC reactions in acute anterior uveitis.

作者信息

Saari K M, Häkli J, Solja J, Kaakinen A, Seppänen S, Kallio S, Kataja M

出版信息

Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1981;216(1):23-9. doi: 10.1007/BF00407773.

Abstract

HLA-A and B antigens were determined in 37 unrelated patients with acute non-granulomatous anterior uveitis (AAU) and in 114 control subjects. HLA-B27 was identified in 31 patients with AAU (83.8%) and in 15 control subjects (13.2%). Fifteen patients (40.5%) had associated rheumatic diseases and all of them (100%) had HLA-B27. Of the 22 patients without any associated disease, 16 (72.7%) had HLA-B277. To study the HLA-D composition MLC tests were done as one-way microcultures between members of four groups consisting of 10, 10, 8, 8 patients with AAU and two or three healthy controls in each test group. No difference between patient-to-patient reactions as compared with the control reactions could be observed. The results show that AAU is very closely associated with HLA-B27 but not with any of the HLA-D antigens.

摘要

对37例急性非肉芽肿性前葡萄膜炎（AAU）非亲属患者和114例对照者进行了HLA - A和B抗原检测。在31例AAU患者（83.8%）和15例对照者（13.2%）中鉴定出HLA - B27。15例患者（40.5%）患有相关的风湿性疾病，所有这些患者（100%）均有HLA - B27。在22例无任何相关疾病的患者中，16例（72.7%）有HLA - B27。为研究HLA - D组成，进行了混合淋巴细胞培养试验，试验为单向微量培养，四个组每组分别由10例、10例、8例、8例AAU患者组成，每个试验组有两到三名健康对照者。未观察到患者之间反应与对照反应有差异。结果表明，AAU与HLA - B27密切相关，但与任何HLA - D抗原均无关联。