通过皮肤移植存活时间和混合淋巴细胞反应测定的人类HL - A单倍型的免疫原性。
The immunogenicity of human HL-A haplotypesas measured by skin graft survival times and mixed leukocyte reactions.
作者信息
Seigler H F, Ward F E, Amos D B, Phaup M B, Stickel D L
出版信息
J Exp Med. 1971 Mar 1;133(3):411-23. doi: 10.1084/jem.133.3.411.
Abstract
The immunogenicity of the haplotypes in 30 families was measured by survival of skin grafts between selected paired family members. These families were genotyped for HL-A using 57 selected cytotoxic alloantisera defining HL-A 1-12 as well as other nondefined specificities. Mixed leukocyte reactions were also studied in this series and the correlations between the mixed leukocyte reactions with skin graft survival times, individual HL-A specificities, and the number of incompatible HL-A alleles are reported. Comments concerning the interpretation and quantitation of the mixed leukocyte reactions are discussed.
摘要
通过选定的配对家庭成员之间皮肤移植的存活情况来测定30个家庭中单体型的免疫原性。使用57种选定的细胞毒性同种异体抗血清对这些家庭进行HL - A基因分型，这些抗血清可确定HL - A 1 - 12以及其他未明确的特异性。本系列研究还进行了混合淋巴细胞反应，并报告了混合淋巴细胞反应与皮肤移植存活时间、个体HL - A特异性以及不相容HL - A等位基因数量之间的相关性。讨论了有关混合淋巴细胞反应解释和定量的评论。
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