Uvnäs-Wallensten K, Larsson I, Johansson C, Efendic S
Scand J Gastroenterol. 1979;14(7):797-800. doi: 10.3109/00365527909181407.
The effect of variations of intra-antral pH on the intraluminal release of somatostatin was studied. Acute pouches were created in anaesthetized cats, and the pouches were perfused with solutions differing in pH. Somatostatin levels were then measured in the perfusates. In this model phosphate buffer was a potent stimulator of intra-antral somatostatin release, whereas perfusion with 0.1 M HCl failed to release somatostatin by itself. Since phosphate buffer also releases gastrin, the releasing effect ought to be exerted beyond the mechanism that can be blocked by somatostatin. (Thus the stimulatory effect of phosphate buffer might be exerted on the membranes of the endocrine cells.)
研究了窦腔内pH值变化对生长抑素腔内释放的影响。在麻醉的猫身上制作急性袋囊，并向袋囊中灌注pH值不同的溶液。然后测量灌注液中的生长抑素水平。在该模型中，磷酸盐缓冲液是窦腔内生长抑素释放的有效刺激物，而用0.1 M盐酸灌注本身并不能释放生长抑素。由于磷酸盐缓冲液也能释放胃泌素，其释放作用应该是通过生长抑素无法阻断的机制发挥的。（因此，磷酸盐缓冲液的刺激作用可能是作用于内分泌细胞的膜上。）
