胶原血管疾病患者的“毛细血管通透性”
"Capillary permeability" in patients with collagen vascular diseases.
作者信息
Marks J, Birkett D A, Shuster S
出版信息
Br Med J. 1972 Mar 25;1(5803):782-4. doi: 10.1136/bmj.1.5803.782.
"Capillary permeability" to serum albumin has been measured in patients with collagen vascular diseases by a method which compares the dilution of intravenously injected (131)I-human serum albumin and (51)Cr-R.B.C.s. The results indicate an increased capillary permeability comparable to that which occurs in patients with extensive inflammatory skin disease. We suggest that this increased capillary permeability may be the cause of the episodes of oedema which occur in patients with collagen vascular diseases such as disseminated lupus erythematosus, systemic sclerosis, dermatomyositis, polyarteritis nodosa, and rheumatoid arthritis. "Spontaneous periodic oedema" may be the presenting feature of collagen vascular disease and is due to increased capillary permeability.
通过一种比较静脉注射（131）I - 人血清白蛋白和（51）Cr - 红细胞稀释度的方法，对患有胶原血管疾病的患者进行了血清白蛋白“毛细血管通透性”的测量。结果表明，毛细血管通透性增加，与患有广泛炎症性皮肤病的患者相当。我们认为，这种毛细血管通透性增加可能是患有胶原血管疾病（如播散性红斑狼疮、系统性硬化症、皮肌炎、结节性多动脉炎和类风湿性关节炎）的患者发生水肿发作的原因。“自发性周期性水肿”可能是胶原血管疾病的首发特征，且归因于毛细血管通透性增加。
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