Gemant A
Mol Biol Rep. 1979 Feb 15;4(4):203-6. doi: 10.1007/BF00777554.
Compounds were studied that inhibit the oxidative degradation of human serum albumin by peroxidase and the enzyme model, iron hydroxide. Differences between the two oxidants gave clues for the mechanism of inhibition. The inhibitors studied were inorganic anions, phosphate, sulfate, carbonate and molybdate; organic anions, decanoate and glycocholate; and the nonionic species, glycogen. Such inhibitors might be considered as adjuvants in senescence: by decreasing the rate of enzymic oxidation of essential body proteins, they would, in the course of aging, reduce some of the physiological changes occurring as a result of accumulation of degraded protein.
对能够抑制过氧化物酶和氢氧化铁这种酶模型对人血清白蛋白进行氧化降解的化合物展开了研究。两种氧化剂之间的差异为抑制机制提供了线索。所研究的抑制剂有无机阴离子，如磷酸盐、硫酸盐、碳酸盐和钼酸盐；有机阴离子，如癸酸盐和甘胆酸盐；以及非离子物质糖原。这类抑制剂可被视为衰老过程中的佐剂：通过降低体内必需蛋白质的酶促氧化速率，在衰老过程中，它们会减少因降解蛋白质积累而发生的一些生理变化。
