近交系小鼠中的同种异体效应。II. 建立移植物抗宿主反应增强抗体产生所需的细胞相互作用。
The allogeneic effect in inbred mice. II. Establishment of the cellular interactions required for enhancement of antibody production by the graft-versus-host reaction.
作者信息
Katz D H, Osborne D P
出版信息
J Exp Med. 1972 Sep 1;136(3):455-65. doi: 10.1084/jem.136.3.455.
Abstract
Experimental conditions have been established for the elicitation of an allogeneic effect on the adoptive transfer secondary anti-2,4-dinitrophenyl (DNP) antibody response in mice. Thus, spleen cells from DNP-keyhole limpet hemocyanin (KLH)-primed mice manifest good secondary anti-DNP responses to a challenge with DNP-KLH, but not with DNP-bovine gamma globulin (BGG), after adoptive transfer to irradiated syngeneic recipients. However, a good adoptive transfer secondary anti-DNP response of such cells can be elicited with DNP-BGG when a second transfer of allogeneic lymphoid cells, in appropriate numbers, is carried out 24 hr before secondary challenge. The advantage to this system is that the DNP-primed cell population as well as the population of allogeneic lymphoid cells are accessible to experimental manipulation such that the T lymphocytes of one or the other can be removed. Utilizing this model, we have established that the allogeneic effect on antibody production can operate on a population of primed B lymphocytes which have been depleted of their isologous T lymphocytes by in vitro incubation with anti-theta serum plus complement. The potential cellular interactions involved in the mechanism of this phenomenon are considered and discussed in detail.
摘要
已建立实验条件，以引发对小鼠过继转移二次抗2,4 - 二硝基苯基（DNP）抗体反应的同种异体效应。因此，来自用DNP - 钥孔血蓝蛋白（KLH）致敏小鼠的脾细胞，在过继转移到经照射的同基因受体后，对DNP - KLH攻击表现出良好的二次抗DNP反应，但对DNP - 牛γ球蛋白（BGG）则无反应。然而，当在二次攻击前24小时进行适当数量的同种异体淋巴细胞的第二次转移时，用DNP - BGG可以引发此类细胞良好的过继转移二次抗DNP反应。该系统的优点是，致敏的DNP细胞群体以及同种异体淋巴细胞群体都可用于实验操作，从而可以去除其中一方的T淋巴细胞。利用该模型，我们已确定，对抗体产生的同种异体效应可作用于已通过与抗θ血清加补体进行体外孵育而去除其同源T淋巴细胞的致敏B淋巴细胞群体。本文详细考虑并讨论了该现象机制中潜在的细胞相互作用。
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Mouse thymic iso-antigens.小鼠胸腺同种抗原。
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The allogeneic effect in inbred mice. I. Experimental conditions for the enhancement of hapten-specific secondary antibody responses by the graft-versus-host reaction.近交系小鼠中的同种异体效应。I. 通过移植物抗宿主反应增强半抗原特异性二次抗体反应的实验条件。
J Exp Med. 1972 Sep 1;136(3):439-54. doi: 10.1084/jem.136.3.439.
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Mechanisms involved in the antileukemic effect of immunocompetent allogeneic lymphoid cell transfer.免疫活性同种异体淋巴细胞转移的抗白血病作用所涉及的机制。
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