Howman-Giles R B, Gilday D L, Ash J M
Radiology. 1979 May;131(2):497-502. doi: 10.1148/131.2.497.
Of 63 99mTc-phosphate bone images in 49 patients with neuroblastoma, 41 were abnormal, 17 showed tracer uptake within the primary tumor, 29 showed evidence of skeletal metastatic disease, and 17 demonstrated renal/urinary tract involvement. The metastases were asymmetric in 24 patients and symmetrical in 9, in whom they involved the metaphyses and epiphyses of the long bones. Except for one patient with multiple "cold" areas, all metastases were seen as focal hyperactive regions. Eleven of 42 skeletal radiographic surveys were abnormal. The radionuclide study appears to be more accurate than skeletal radiography in estimating bone involvement in neuroblastoma. Primary tumor concentration of the tracer is almost pathognomonic of neural crest neoplasms in childhood.
在49例神经母细胞瘤患者的63张99mTc磷酸盐骨显像中，41例异常，17例在原发肿瘤内显示示踪剂摄取，29例显示骨骼转移疾病证据，17例显示肾/尿路受累。24例患者的转移灶不对称，9例对称，累及长骨的干骺端和骨骺。除1例有多个“冷”区的患者外，所有转移灶均表现为局灶性高活性区域。42次骨骼X线检查中有11次异常。放射性核素研究在评估神经母细胞瘤的骨受累情况方面似乎比骨骼X线检查更准确。示踪剂在原发肿瘤中的浓聚几乎是儿童期神经嵴肿瘤的特征性表现。
