在奶牛单次静脉输注后磺胺多辛和甲氧苄啶的半衰期。
Half-lives of sulphadoxine and trimethoprim after a single intravenous infusion in cows.
作者信息
Davitiyananda D, Rasmussen F
出版信息
Acta Vet Scand. 1974;15(3):356-65. doi: 10.1186/BF03547464.
Abstract
DAVITIYANANDA, DANIS and FOLKE RASMUSSEN: Acta vet. scand. 1974, , 356–365. — The half-life of sulphadoxine in plasma (11 hrs.) is much longer than that of trimethoprim (50–103 min.) and in accordance to this traces of sulphadoxine are demonstrated in the milk 3 days after the infusion, while trimethoprim could not be detected in milk 2 days after the infusion. The apparent volume of distribution is 0.37 for sulphadoxine and 1.14 for trimethoprim, i.e. 37 % and 114 % of the body weight, respectively. sulphadoxine; trimethoprim; half-life; cow.
摘要
达维蒂亚南达、达尼斯和福尔克·拉斯穆森：《兽医学报》1974年，第 356 - 365 页。——血浆中磺胺多辛的半衰期（11 小时）比甲氧苄啶的半衰期（50 - 103 分钟）长得多，据此，输液 3 天后在牛奶中检测到了磺胺多辛的痕迹，而输液 2 天后牛奶中未检测到甲氧苄啶。磺胺多辛的表观分布容积为 0.37，甲氧苄啶为 1.14，即分别占体重的 37%和 114%。磺胺多辛；甲氧苄啶；半衰期；奶牛。
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