Ploy-Song-Sang Y Y, Loudon R G, Beach B C, Corbin R P
South Med J. 1979 May;72(5):568-72. doi: 10.1097/00007611-197905000-00018.
We performed follow-up pulmonary function studies on three patients with acute pulmonary histoplasmosis over a period of several months, and found that the disease is benign and usually responds well to treatment or is self-limiting. There are four major changes in lung function, namely a restrictive defect, an impairment of diffusing capacity, stiff lung, and obstruction in small airways. These changes usually lead to disturbance of ventilation-perfusion ratios and impaired gas transport across alveolar capillary membranes, resulting in arterial hypoxemia. There is also hypocapnia from alveolar hyperventilation commonly found in restrictive and stiff lung syndrome.
我们对三名急性肺组织胞浆菌病患者进行了为期数月的随访肺功能研究，发现该疾病是良性的，通常对治疗反应良好或具有自限性。肺功能有四个主要变化，即限制性缺陷、弥散功能损害、肺僵硬和小气道阻塞。这些变化通常会导致通气-灌注比例失调以及气体跨肺泡毛细血管膜转运受损，从而导致动脉血氧不足。在限制性和肺僵硬综合征中，通常还会因肺泡过度通气而出现低碳酸血症。
