Burchard G D, Büttner D W, Bierther M
Tropenmed Parasitol. 1979 Mar;30(1):103-12.
Six onchocerca-nodules from five Liberian patients were examined by electron microscopy. The bulk of cells in the centre of the nodules consists of lymphocytes and macrophages. The lymphocytes can be observed in various stages of differentiation. A major part of the macrophages shows degenerative changes with decrease of lysosomes and increase of fatty vacuoles. Near the worms epithelioid cells and giant cells can be found. Other cells in the nodule include polymorphonuclear neutrophils, eosinophils, plasma cells, and mast cells. Adult Onchocerca volvulus show the basic nematode body plan. The cuticle is subdivided into cortex and two layers with differently arranged fibrillar structures. The characteristics of the hypodermal cells are best seen in the lateral chords, in the interchordal regions the hypodermis is flattened by a muscle layer. The intestine typically contains pigment granules, the cells of the epithelium have folds of their cell membranes forming a basal labyrinth. The uterus consists of two tubes in which the development of the microfilariae from the early embryonic forms to the mature stages is examined.
对来自5名利比里亚患者的6个盘尾丝虫结节进行了电子显微镜检查。结节中心的大部分细胞由淋巴细胞和巨噬细胞组成。可观察到处于不同分化阶段的淋巴细胞。大部分巨噬细胞呈现退行性变化，溶酶体减少，脂肪空泡增加。在虫体附近可发现上皮样细胞和巨细胞。结节中的其他细胞包括多形核中性粒细胞、嗜酸性粒细胞、浆细胞和肥大细胞。旋盘尾丝虫成虫呈现基本的线虫体型。角质层分为皮质和两层具有不同排列纤维结构的层。皮下细胞的特征在侧索中最为明显，在索间区域，皮下组织被一层肌肉层压扁。肠道通常含有色素颗粒，上皮细胞的细胞膜有褶皱，形成基底迷路。子宫由两根管道组成，在其中检查微丝蚴从早期胚胎形式到成熟阶段的发育情况。
