Burchard G D, Bierther M
Tropenmed Parasitol. 1978 Dec;29(4):451-61.
Skin biopsies of 22 untreated Liberian patients suffering from onchocercal dermatitis were studied by electron microscopy. The microfilariae tend to accumulate in the upper dermis, without eliciting a cellular reaction. Occasionally macrophages or mast cells are found in the neighbourhood of the microfilariae. The most conspicuous changes concern the presence of perivascular infiltrates, comprised of lymphocytes and macrophages, with a varying admixture of plasma cells. Only exceptionally the macrophages show an increase in number and size of their lysosomes and pseudopodia as well as prominent strands of ergastoplasm indicating an activation. The endothelial walls of the dermal vessels are swollen. The amount of mast cells in the upper dermis is increased. Ultrastructural features of the microfilariae are described, especially the cuticle, muscles, central undifferentiated cells and cephalic region. When comparing these findings with the literature on the fine structural morphology of the Latinamerican form, no differences can be found.
对22名未经治疗的患有盘尾丝虫性皮炎的利比里亚患者进行了皮肤活检，并通过电子显微镜进行研究。微丝蚴倾向于在上层真皮中积聚，未引发细胞反应。偶尔在微丝蚴附近发现巨噬细胞或肥大细胞。最明显的变化是存在由淋巴细胞和巨噬细胞组成的血管周围浸润，并伴有不同比例的浆细胞。仅在极少数情况下，巨噬细胞的溶酶体和伪足数量及大小增加，内质网明显增多，表明其被激活。真皮血管的内皮壁肿胀。上层真皮中肥大细胞的数量增加。描述了微丝蚴的超微结构特征，特别是角质层、肌肉、中央未分化细胞和头部区域。将这些发现与有关拉丁美洲型微丝蚴精细结构形态的文献进行比较时，未发现差异。
