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人体甲状腺激素对长期寒冷暴露的反应。

Thyroid hormone response to prolonged cold exposure in man.

作者信息

Eastman C J, Ekins R P, Leith I M, Williams E S

出版信息

J Physiol. 1974 Aug;241(1):175-81. doi: 10.1113/jphysiol.1974.sp010647.

DOI:10.1113/jphysiol.1974.sp010647
PMID:4422816
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1331079/
Abstract
  1. Four men, of ages varying from 23 to 28 years, living at Halley Bay, Antarctica (75 degrees 31' S, 26 degrees 39' W), were exposed to a mean air temperature of 6.6 degrees C.2. The concentration of serum triiodothyronine (T(3)) rose significantly by the second day, remained raised, and returned to pre-exposure levels within 2 days of return to a normal environment.3. The concentration of serum thyroxine (T(4)) rose more slowly than did the T(3), reaching a maximum in 3-4 days and also returning to normal within 2 days of return to a normal environment.4. There was a wide individual variation in the change of concentration of serum cortisol.
摘要

  1. 四名年龄在23至28岁之间的男子居住在南极洲哈雷湾（南纬75度31分，西经26度39分），他们暴露在平均气温为6.6摄氏度的环境中。

  2. 血清三碘甲状腺原氨酸（T₃）浓度在第二天显著升高，持续升高，并在回到正常环境后2天内恢复到暴露前水平。

  3. 血清甲状腺素（T₄）浓度的升高比T₃慢，在3 - 4天达到最高值，同样在回到正常环境后2天内恢复正常。

  4. 血清皮质醇浓度变化存在很大的个体差异。

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Thyroid hormone response to prolonged cold exposure in man.人体甲状腺激素对长期寒冷暴露的反应。
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Decreased free fraction of thyroid hormones after prolonged Antarctic residence.长期居住在南极后甲状腺激素的游离部分减少。
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本文引用的文献

1
The effect of varying temperatures on thyroid activity and the survival of rats exposed to cold and treated with L-thyroxine or corticosterone.不同温度对甲状腺活性以及暴露于寒冷环境并接受L-甲状腺素或皮质酮治疗的大鼠存活率的影响。
J Endocrinol. 1967 Apr;37(4):355-9. doi: 10.1677/joe.0.0370355.
2
Cardiovascular and metabolic responses to noradrenaline in man, before and after acclimatization to cold in Antarctica.在南极洲适应寒冷前后，人体对去甲肾上腺素的心血管和代谢反应。
J Physiol. 1966 Sep;186(1):233-42. doi: 10.1113/jphysiol.1966.sp008031.
3
Thyroxine deiodination during cold exposure in the rat.大鼠冷暴露期间的甲状腺素脱碘作用
J Physiol. 1968 Jul;197(1):135-47. doi: 10.1113/jphysiol.1968.sp008551.
4
Temperature acclimation in birds and mammals.鸟类和哺乳动物的温度适应
Annu Rev Physiol. 1971;33:155-202. doi: 10.1146/annurev.ph.33.030171.001103.
5
Pathological consequences of artificial cold acclimatization.
Nature. 1970 Jul 4;227(5253):88-9. doi: 10.1038/227088a0.
6
Initial response of human thyroid, adrenal cortex, and adrenal medulla to acute cold exposure.人体甲状腺、肾上腺皮质和肾上腺髓质对急性冷暴露的初始反应。
Can J Physiol Pharmacol. 1967 May;45(3):423-32. doi: 10.1139/y67-051.