Williams B D, Clarkson A R, Row P G, Groves R J, Cameron J S
Br Med J. 1974 Oct 5;4(5935):21-3. doi: 10.1136/bmj.4.5935.21.
C3 and fibrin degradation products (F.D.P.) have been measured in early morning urine samples from 38 normal people and 123 patients with glomerulonephritis. Normal urine contained less than 0.3 mug of either antigen per ml. C3 and F.D.P. were both detected in the urine of many patients with glomerulonephritis. Levels above 1 mug/ml were exceptional in patients with "minimal change," and the highest excretion of both antigens occurred in mesangiocapillary glomerulonephritis, membranous nephropathy, and focal glomerulosclerosis.Both C3 and F.D.P. excretion showed considerable variation with time, with parellel fluctuations in the two antigens. These fluctuations did not depend on the total protein leakage and suggest that the complement and clotting sequence are closely related in these glomerular disorders.
对38名正常人和123名肾小球肾炎患者清晨尿液样本中的C3和纤维蛋白降解产物（F.D.P.）进行了检测。正常尿液中每毫升两种抗原的含量均低于0.3微克。许多肾小球肾炎患者的尿液中均检测到了C3和F.D.P.。在“微小病变”患者中，含量高于1微克/毫升的情况较为罕见，两种抗原排泄量最高的情况出现在系膜毛细血管性肾小球肾炎、膜性肾病和局灶性肾小球硬化症患者中。C3和F.D.P.的排泄量均随时间有显著变化，两种抗原呈现平行波动。这些波动并不取决于总蛋白漏出情况，提示在这些肾小球疾病中补体和凝血过程密切相关。
