乳腺癌生存与宿主抵抗力的关系。
Host resistance in relation to survival in breast cancer.
作者信息
Di Paola M, Angelini L, Bertolotti A, Colizza S
出版信息
Br Med J. 1974 Nov 2;4(5939):268-70. doi: 10.1136/bmj.4.5939.268.
Abstract
The degree of lymphocytic infiltration in and around breast tumours together with sinus histiocytosis and follicular hyperplasia in regional lymph nodes has been studied in 310 cases of breast cancer treated with standard radical mastectomy. The presence of these features was regarded as evidence of host resistance against the tumour and made possible the division of patients into three classes-no or poor reaction, good reaction, and strong reaction. The grading was shown to have a close correlation with prognosis. The relationship between host defensive factor grading and malignancy, nodal metastases, and survival was also examined. The results support the hypothesis that prognosis in breast cancer is closely related to a histological picture of cell-mediated immunity against the tumour.
摘要
对310例行标准根治性乳房切除术的乳腺癌患者，研究了乳腺肿瘤内及周围的淋巴细胞浸润程度，以及区域淋巴结内的窦组织细胞增生和滤泡增生情况。这些特征的存在被视为宿主对肿瘤产生抵抗的证据，据此可将患者分为三类：无反应或反应差、反应良好、反应强烈。结果表明，这种分级与预后密切相关。还研究了宿主防御因子分级与恶性程度、淋巴结转移及生存之间的关系。这些结果支持了以下假说：乳腺癌的预后与针对肿瘤的细胞介导免疫的组织学表现密切相关。
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Host resistance in relation to survival in breast cancer.乳腺癌生存与宿主抵抗力的关系。
Br Med J. 1974 Nov 2;4(5939):268-70. doi: 10.1136/bmj.4.5939.268.
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