体外产生对移植抗原具有反应性的记忆淋巴细胞。
In vitro generation of memory lymphocytes reactive to transplantation antigens.
作者信息
Hollander N, Ginsburg H, Feldman M
出版信息
J Exp Med. 1974 Oct 1;140(4):1057-67. doi: 10.1084/jem.140.4.1057.
Abstract
The in vitro generation of memory cells reactive to transplantation antigens is described. Blast cells, obtained from rat lymphocytes sensitized on xenogeneic or allogeneic fibroblast monolayers, reverted to secondary small lymphocytes after transfer from the foreign sensitizing to syngeneic monolayers. These secondary small lymphocytes had a limited in vitro life span of 4-6 wk. They manifested properties of memory cells: upon re-exposure to fibroblasts of the sensitizing phenotype, the secondary lymphocytes adhered to the fibroblast monolayer and transformed into blast cells with cytotoxic activity. The response of secondary lymphocytes was rapid, compared to that of normal lymphocytes, and directed specifically against the primary sensitizing antigens.
摘要
本文描述了对移植抗原产生反应的记忆细胞的体外生成。从在异种或同种异体成纤维细胞单层上致敏的大鼠淋巴细胞中获得的母细胞，在从异源致敏单层转移到同基因单层后，恢复为次级小淋巴细胞。这些次级小淋巴细胞在体外的寿命有限，为4 - 6周。它们表现出记忆细胞的特性：再次接触致敏表型的成纤维细胞时，次级淋巴细胞粘附于成纤维细胞单层并转化为具有细胞毒性活性的母细胞。与正常淋巴细胞相比，次级淋巴细胞的反应迅速，且特异性针对初次致敏抗原。
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