Tos M, Mogensen C
Acta Otolaryngol. 1979 Mar-Apr;87(3-4):317-23. doi: 10.3109/00016487909126426.
In 20 rabbits one nostril was closed surgically and the nasal mucosa lying anteriorly in the vestibule was studied 4--90 days postoperatively. On the occluded side, without air-flow, the epithelium--which at this site is normally thickened due to hyperplasia of basal cells--gradually returned to a normal thinner, regular epithelium with increased number of goblet cells. On the patent side, where the airflow was doubled, the cilia were damaged. As early as the 4th day, a process of repair had been initiated, with hyperplasia of basal cells and differentiation of these cells into ciliated and goblet cells. As a result of continued trauma, similar processes continued, but there were no signs of a permanent transformation of the epithelium into squamous epithelium, not even on the 90th day.
在20只兔子中，手术封闭一侧鼻孔，并在术后4至90天研究前庭前部的鼻黏膜。在闭塞侧，由于没有气流，该部位通常因基底细胞增生而增厚的上皮逐渐恢复为正常的较薄、规则的上皮，杯状细胞数量增加。在通畅侧，气流增加一倍，纤毛受到损伤。早在第4天就开始了修复过程，基底细胞增生并分化为纤毛细胞和杯状细胞。由于持续的创伤，类似的过程持续存在，但即使在第90天，也没有上皮永久性转化为鳞状上皮的迹象。
