Tos M, Mogensen C
J Laryngol Otol. 1978 Aug;92(8):667-80. doi: 10.1017/s0022215100085935.
In 20 rabbits one nostril was closed surgically for 4, 10, 16, 20, 60 and 90 days, and thereafter the mucous membranes from the open and closed sides of the nose were investigated. Anteriorly on the open side a process of repair started as early as the 4th day after ciliary damage. This process consisted in hyperplasia of basal cells, displacement and gradual desquamation of ciliated cells and goblet cells, differentiation of basal cells into ciliated and goblet cells. On the 16th day the epithelium was again ciliated. As a result of a continued abnormally increased airflow new damage to the cilia occurred and a new cycle was initiated, so that on the 30th and 90th days the epithelium was again ciliated. Even though the epithelium is 'squamous-like' in some phases, there is no question of a transformation into squamous epithelium. On the closed side anteriorly there is increased secretory activity in the epithelium. Posteriorly blind quantitative histology showed no differences between the open and the closed side, or between 'treated' and control material.
在20只兔子中，一侧鼻孔手术封闭4天、10天、16天、20天、60天和90天，之后对鼻腔开放侧和封闭侧的黏膜进行研究。在开放侧，早在纤毛受损后第4天就开始了修复过程。这个过程包括基底细胞增生、纤毛细胞和杯状细胞移位并逐渐脱落，基底细胞分化为纤毛细胞和杯状细胞。在第16天，上皮再次出现纤毛。由于气流持续异常增加，纤毛再次受损并开始新的循环，因此在第30天和第90天，上皮再次出现纤毛。尽管上皮在某些阶段呈“鳞状样”，但不存在转化为鳞状上皮的问题。在封闭侧前部，上皮的分泌活动增强。在后部，盲法定量组织学显示开放侧与封闭侧之间、“处理”材料与对照材料之间没有差异。
