Tos M, Mogensen C
Rhinology. 1979 Dec;17(4):215-25.
In 20 rabbits one nostril was surgically closed and the mucous membrane studied 4--90 days after the operation. The density of goblet cells was determined anteriorly and posteriorly on whole mounts, epithelial changes on serial sections from 4 different localities on the septum. Anteriorly on the open side damage to the cilia initiated epithelial processes of repair, viz. hyperplasia of basal cells, transformation of these cells into columnar cells, and differentiation into mucous and ciliated cells. On the 16th day the epithelium was again columnar and ciliated. As a consequence of continued trauma new cycles were initiated, but not even after 90 days was there any squamous epithelium. In the middle and posteriorly on the septum no changes were demonstrated, indicating a marked, but gradual decrease in the anteroposterior direction of the influence by the air-flow upon the mucosa. On the closed side there was increased secretory activity and normalization of the epithelium which was changed most anteriorly in normal rabbits.
在20只兔子中，通过手术封闭一侧鼻孔，并在术后4至90天对其黏膜进行研究。在整个标本上，分别在前方和后方测定杯状细胞的密度，从鼻中隔4个不同部位的连续切片观察上皮变化。在开放侧的前方，纤毛受损引发上皮修复过程，即基底细胞增生，这些细胞转化为柱状细胞，并分化为黏液细胞和纤毛细胞。在第16天，上皮再次变为柱状且有纤毛。由于持续创伤，新的周期开始，但即使在90天后也未出现鳞状上皮。在鼻中隔的中部和后部未显示出变化，这表明气流对黏膜的影响在前后方向上明显但逐渐减弱。在封闭侧，分泌活动增强，上皮恢复正常，而在正常兔子中，此处上皮变化最为明显。
