Bergsjø T, Nafstad I, Ingebrigtsen K
Acta Vet Scand. 1979;20(1):25-37. doi: 10.1186/BF03546626.
The distribution of S-labelled sulfadiazine and G-labelled trimethoprim was studied in rainbow trout by use of whole body autoradiography and liquid scintillation. As compared to mammals, gastrointestinal absorption and elimination were slow. Accumulation in the skin and the uveal tract of the eye was observed for both drugs tested. The results also indicated that the bile was an important route of excretion. Considerable radioactivity was still present in the skin at 144 hr. survival time.
通过全身放射自显影和液体闪烁法研究了 S 标记的磺胺嘧啶和 G 标记的甲氧苄啶在虹鳟鱼体内的分布。与哺乳动物相比，胃肠道的吸收和消除较慢。在所测试的两种药物中均观察到它们在皮肤和眼葡萄膜中的蓄积。结果还表明，胆汁是一条重要的排泄途径。在存活 144 小时时，皮肤中仍存在相当数量的放射性。
