Dencker L, Lindquist N G, Ullberg S
Toxicology. 1975 Nov;5(2):255-65. doi: 10.1016/0300-483x(75)90122-5.
Whole body autoradiography of a pregnant monkey (Macaca irus) of late gestation was performed 72 h after an intravenous injection of the 125I-labelled chloroquine analogue 4-(3-dimethylaminopropylamino)-7-iodoquinoline (DAPQ). The overall distribution pattern in the monkey was similar to that which was earlier observed in rodents. A few species differences, however, were found in the monkey as compared to the rodents: a high accumulation in the inner part of the adrenal cortex, a high level in the central nervous system, and generally a higher retention in the tissues. The accumulation in the adrenal cortex may be of significance for the cortisone-like effects of the 4-aminoquinolines in rheumatoid arthritis and allied conditions. The fact that no accumulation was found in the adrenal cortex of mice and rats indicates that these species may not be appropriate in studies on the mechanisms involved in the anti-inflammatory action of the 4-aminoquinolines. As was earlier observed in small rodents the melanin containing structures accumulated the drug. In both the mother and the fetus a high concentration was thus seen in the uveal tract of the eye, in the inner ear (in the stria vascularis of the cochlea and the planum semilunatum of the ampullae) and in the hair follicles. This accumulation can be related to reported disturbances--also transplacentally induced--in vision and hearing.
在静脉注射125I标记的氯喹类似物4-(3-二甲基氨基丙基氨基)-7-碘喹啉（DAPQ）72小时后，对一只妊娠晚期的猕猴（食蟹猴）进行了全身放射自显影。猕猴体内的总体分布模式与先前在啮齿动物中观察到的相似。然而，与啮齿动物相比，在猕猴中发现了一些物种差异：肾上腺皮质内部有高积累，中枢神经系统中有高水平，并且组织中的保留通常更高。肾上腺皮质中的积累可能与4-氨基喹啉在类风湿性关节炎及相关病症中的可的松样作用有关。在小鼠和大鼠的肾上腺皮质中未发现积累这一事实表明，这些物种可能不适用于研究4-氨基喹啉抗炎作用所涉及的机制。正如早期在小型啮齿动物中观察到的那样，含黑色素的结构积累了该药物。因此，在母体和胎儿的眼睛葡萄膜、内耳（耳蜗的血管纹和壶腹的半月形平面）和毛囊中都观察到了高浓度。这种积累可能与所报道的——也可经胎盘诱导的——视觉和听觉障碍有关。
