Murray P K, Jennings F W, Murray M, Urquhart G M
Immunology. 1974 Nov;27(5):825-40.
In an investigation of the immunosuppression associated with trypanosomiasis, the thymus-derived lymphocytes (T cells) and the thymus-independent lymphocytes (B cells) in mice with subacute infections were studied. It was shown that: (a) there was a massive plasma cell response in lymph nodes and spleen which replaced the thymus-dependent areas; (b) a failure of antibody production at the cellular level occurred as shown by the absence of IgM PFC responses to SRBC and lipopolysaccharide; (c) T cells appeared relatively normal as judged by their ability to proliferate following a primary stimulus with oxazolone unless measured during the terminal stages of the disease; (d) immune competence was rapidly restored after treatment with a trypanocidal drug. It appeared that immunosuppression was closely associated with the presence of living trypanosomes, possibly mediated through a B-cell defect. The mechanism whereby this might occur is discussed.
在一项关于与锥虫病相关的免疫抑制的研究中，对患有亚急性感染的小鼠体内源自胸腺的淋巴细胞（T细胞）和不依赖胸腺的淋巴细胞（B细胞）进行了研究。结果表明：（a）淋巴结和脾脏中出现大量浆细胞反应，取代了依赖胸腺的区域；（b）如对绵羊红细胞和脂多糖缺乏IgM空斑形成细胞反应所示，在细胞水平上发生了抗体产生障碍；（c）除非在疾病末期进行测量，根据其在用恶唑酮进行初次刺激后增殖的能力判断，T细胞看起来相对正常；（d）用杀锥虫药物治疗后免疫能力迅速恢复。看来免疫抑制与活锥虫的存在密切相关，可能是通过B细胞缺陷介导的。文中讨论了这种情况可能发生的机制。
