小鼠体内75硒标记布氏锥虫的免疫清除。II. 免疫动物中的机制。
Immunological clearance of 75Se-labelled Trypanosoma brucei in mice. II. Mechanisms in immune animals.
作者信息
Macaskill J A, Holmes P H, Whitelaw D D, McConnell I, Jennings F W, Urquhart G M
出版信息
Immunology. 1980 Aug;40(4):629-35.
Abstract
Using trypanosomes labelled with [75Se]-methionine a series of experiments was conducted to investigate the respective roles of antibody, macrophage activtion and complement in the removal of trypanosomes from the circulation of immune mice. It was found that clearance in such animals is largely accomplished by antibody-mediated hepatic phagocytosis, which, at least in passively immunized animals, is dependent on opsonization involving C3. No evidence was found to suggest that intravascular lysis or activated macrophages are involved in immune clearance.
摘要
利用用[75硒] - 甲硫氨酸标记的锥虫进行了一系列实验，以研究抗体、巨噬细胞激活和补体在免疫小鼠循环系统中清除锥虫的各自作用。结果发现，此类动物体内的清除主要通过抗体介导的肝脏吞噬作用来完成，至少在被动免疫的动物中，这依赖于涉及C3的调理作用。未发现有证据表明血管内裂解或活化的巨噬细胞参与免疫清除。
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本文引用的文献
1
Passive immunity to experimental trypanosomiasis.
J Parasitol. 1966 Dec;52(6):1134-40.
2
The pathology of African trypanosomiasis.非洲锥虫病的病理学
Trans R Soc Trop Med Hyg. 1970;64(6):797-817. doi: 10.1016/0035-9203(70)90096-9.
3
Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose.使用二乙氨基乙基纤维素从人和其他哺乳动物中分离涎源性锥虫。
Exp Parasitol. 1970 Dec;28(3):521-34. doi: 10.1016/0014-4894(70)90120-7.
4
The nature of immunosuppression in Trypanosoma brucei infections in mice. I. The role of the macrophage.小鼠布氏锥虫感染中免疫抑制的本质。I. 巨噬细胞的作用。
Immunology. 1974 Nov;27(5):815-24.
5
Immune serum-mediated cytotoxicity against Trypanosoma rhodesiense.免疫血清介导的针对罗德西亚锥虫的细胞毒性作用。
J Immunol. 1976 Apr;116(4):1005-9.
6
Trypanosoma musculi infections in normocomplementemic, C5-deficient, and C3-depleted mice.正常补体、C5缺陷和C3缺失小鼠中的鼠锥虫感染。
Infect Immun. 1977 May;16(2):557-63. doi: 10.1128/iai.16.2.557-563.1977.
7
Ultrastructural and immunological aspects of the phagocytosis of Trypanosoma brucei by mouse peritoneal macrophages.小鼠腹腔巨噬细胞对布氏锥虫吞噬作用的超微结构和免疫学方面
Infect Immun. 1978 Mar;19(3):972-82. doi: 10.1128/iai.19.3.972-982.1978.
8
Activation of complement by variant-specific surface antigen of trypanosoma brucei.布氏锥虫变体特异性表面抗原激活补体
Nature. 1977 Dec 1;270(5636):438-40. doi: 10.1038/270438a0.
9
10
Evidence implicating the mononuclear phagocytic system of the rat in immunity to infections with Trypanosoma lewisi.
Aust J Exp Biol Med Sci. 1978 Apr;56(2):201-9. doi: 10.1038/icb.1978.22.
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