小鼠体内75硒标记布氏锥虫的免疫清除。II. 免疫动物中的机制。
Immunological clearance of 75Se-labelled Trypanosoma brucei in mice. II. Mechanisms in immune animals.
作者信息
Macaskill J A, Holmes P H, Whitelaw D D, McConnell I, Jennings F W, Urquhart G M
出版信息
Immunology. 1980 Aug;40(4):629-35.
Abstract
Using trypanosomes labelled with [75Se]-methionine a series of experiments was conducted to investigate the respective roles of antibody, macrophage activtion and complement in the removal of trypanosomes from the circulation of immune mice. It was found that clearance in such animals is largely accomplished by antibody-mediated hepatic phagocytosis, which, at least in passively immunized animals, is dependent on opsonization involving C3. No evidence was found to suggest that intravascular lysis or activated macrophages are involved in immune clearance.
摘要
利用用[75硒] - 甲硫氨酸标记的锥虫进行了一系列实验，以研究抗体、巨噬细胞激活和补体在免疫小鼠循环系统中清除锥虫的各自作用。结果发现，此类动物体内的清除主要通过抗体介导的肝脏吞噬作用来完成，至少在被动免疫的动物中，这依赖于涉及C3的调理作用。未发现有证据表明血管内裂解或活化的巨噬细胞参与免疫清除。
相似文献
1
Immunological clearance of 75Se-labelled Trypanosoma brucei in mice. II. Mechanisms in immune animals.小鼠体内75硒标记布氏锥虫的免疫清除。II. 免疫动物中的机制。
Immunology. 1980 Aug;40(4):629-35.
2
3
4
5
Anti-Trypanosoma brucei activity of nonprimate zoo sera.非灵长类动物园血清的抗布氏锥虫活性。
J Parasitol. 1999 Feb;85(1):48-53.
6
7
Immune mechanism facilitating clearance of Trypanosoma gambiense by IgG3 antibody from infected host.促进IgG3抗体从受感染宿主清除冈比亚锥虫的免疫机制。
Trop Med Parasitol. 1991 Dec;42(4):394-8.
8
Attachment and ingestion of Trypanosoma gambiense to the rat macrophage by specific antiserum.冈比亚锥虫通过特异性抗血清与大鼠巨噬细胞的附着和摄取。
J Parasitol. 1974 Apr;60(2):336-9.
9
Innate resistance to experimental African trypanosomiasis: differences in cytokine (TNF-alpha, IL-6, IL-10 and IL-12) production by bone marrow-derived macrophages from resistant and susceptible mice.对实验性非洲锥虫病的先天抗性：抗性和易感小鼠骨髓来源巨噬细胞产生细胞因子（肿瘤坏死因子-α、白细胞介素-6、白细胞介素-10和白细胞介素-12）的差异
Cytokine. 2000 Jul;12(7):1024-34. doi: 10.1006/cyto.2000.0685.
引用本文的文献
1
Cholesterol Efflux Decreases TLR4-Target Gene Expression in Cultured Macrophages Exposed to Ghosts.胆固醇流出减少暴露于鬼臼毒素的培养巨噬细胞中TLR4靶基因的表达。
Microorganisms. 2024 Aug 22;12(8):1730. doi: 10.3390/microorganisms12081730.
2
CXCR6+CD4+ T cells promote mortality during Trypanosoma brucei infection.CXCR6+CD4+ T 细胞促进感染布氏锥虫时的死亡率。
PLoS Pathog. 2021 Oct 6;17(10):e1009968. doi: 10.1371/journal.ppat.1009968. eCollection 2021 Oct.
3
Trypanosoma brucei triggers a broad immune response in the adipose tissue.布氏锥虫在脂肪组织中引发广泛的免疫反应。
PLoS Pathog. 2021 Sep 15;17(9):e1009933. doi: 10.1371/journal.ppat.1009933. eCollection 2021 Sep.
4
To the Skin and Beyond: The Immune Response to African Trypanosomes as They Enter and Exit the Vertebrate Host.从皮肤到全身：非洲锥虫进入和离开脊椎动物宿主时的免疫反应。
Front Immunol. 2020 Jun 12;11:1250. doi: 10.3389/fimmu.2020.01250. eCollection 2020.
5
Infections With Extracellular Trypanosomes Require Control by Efficient Innate Immune Mechanisms and Can Result in the Destruction of the Mammalian Humoral Immune System.胞外锥体虫感染需要有效的先天免疫机制来控制，并且可能导致哺乳动物体液免疫系统的破坏。
Front Immunol. 2020 Mar 11;11:382. doi: 10.3389/fimmu.2020.00382. eCollection 2020.
6
Host Immune Responses and Immune Evasion Strategies in African Trypanosomiasis.宿主免疫反应与非洲锥虫病的免疫逃避策略。
Front Immunol. 2019 Nov 22;10:2738. doi: 10.3389/fimmu.2019.02738. eCollection 2019.
7
CRIg plays an essential role in intravascular clearance of bloodborne parasites by interacting with complement.CRIg 通过与补体相互作用，在血源寄生虫的血管内清除中发挥重要作用。
Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24214-24220. doi: 10.1073/pnas.1913443116. Epub 2019 Nov 13.
8
Escaping the immune system by DNA repair and recombination in African trypanosomes.通过 DNA 修复和重组逃避非洲锥虫的免疫系统。
Open Biol. 2019 Nov 29;9(11):190182. doi: 10.1098/rsob.190182. Epub 2019 Nov 13.
9
Interferon Gamma in African Trypanosome Infections: Friends or Foes?γ干扰素在非洲锥虫感染中的作用：是友还是敌？
Front Immunol. 2017 Sep 7;8:1105. doi: 10.3389/fimmu.2017.01105. eCollection 2017.
10
IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4+ T Cells and IFN-γ.白细胞介素-27信号传导对于感染非洲锥虫的小鼠的存活至关重要，其通过预防CD4 + T细胞和干扰素-γ的致死作用来实现。
PLoS Pathog. 2015 Jul 29;11(7):e1005065. doi: 10.1371/journal.ppat.1005065. eCollection 2015 Jul.
本文引用的文献
1
Passive immunity to experimental trypanosomiasis.
J Parasitol. 1966 Dec;52(6):1134-40.
2
The pathology of African trypanosomiasis.非洲锥虫病的病理学
Trans R Soc Trop Med Hyg. 1970;64(6):797-817. doi: 10.1016/0035-9203(70)90096-9.
3
Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose.使用二乙氨基乙基纤维素从人和其他哺乳动物中分离涎源性锥虫。
Exp Parasitol. 1970 Dec;28(3):521-34. doi: 10.1016/0014-4894(70)90120-7.
4
The nature of immunosuppression in Trypanosoma brucei infections in mice. I. The role of the macrophage.小鼠布氏锥虫感染中免疫抑制的本质。I. 巨噬细胞的作用。
Immunology. 1974 Nov;27(5):815-24.
5
Immune serum-mediated cytotoxicity against Trypanosoma rhodesiense.免疫血清介导的针对罗德西亚锥虫的细胞毒性作用。
J Immunol. 1976 Apr;116(4):1005-9.
6
Trypanosoma musculi infections in normocomplementemic, C5-deficient, and C3-depleted mice.正常补体、C5缺陷和C3缺失小鼠中的鼠锥虫感染。
Infect Immun. 1977 May;16(2):557-63. doi: 10.1128/iai.16.2.557-563.1977.
7
Ultrastructural and immunological aspects of the phagocytosis of Trypanosoma brucei by mouse peritoneal macrophages.小鼠腹腔巨噬细胞对布氏锥虫吞噬作用的超微结构和免疫学方面
Infect Immun. 1978 Mar;19(3):972-82. doi: 10.1128/iai.19.3.972-982.1978.
8
Activation of complement by variant-specific surface antigen of trypanosoma brucei.布氏锥虫变体特异性表面抗原激活补体
Nature. 1977 Dec 1;270(5636):438-40. doi: 10.1038/270438a0.
9
10
Evidence implicating the mononuclear phagocytic system of the rat in immunity to infections with Trypanosoma lewisi.
Aust J Exp Biol Med Sci. 1978 Apr;56(2):201-9. doi: 10.1038/icb.1978.22.
Zotero 插件