Bullock W E, Artz R P, Bhathena D, Tung K S
Arch Intern Med. 1979 Jun;139(6):700-2. doi: 10.1001/archinte.139.6.700.
A patient with disseminated histoplasmosis, eosinophilia, and transient mesangiopathic glomerulonephritis stimulated a search for the presence of circulating immune complexes. Serum samples obtained on the fifth and 11th hospital days were strongly positive for ciculating immune complexes by both the Raji cell radioassay and the C1q solid phase assay. During the course of complete clinical recovery without therapy, both assays were weakly positive for circulating immune complexes on day 33. On day 56 they were negative. Using this case as a prototype, possible mechanisms for the renal immunopathology and the eosinophilic response are discussed with reference to the immunological perturbations thay may be observed in systemic mycotic infection.
一名患有播散性组织胞浆菌病、嗜酸性粒细胞增多症和短暂性系膜增生性肾小球肾炎的患者促使人们去寻找循环免疫复合物的存在。在住院第5天和第11天采集的血清样本，通过拉吉细胞放射测定法和C1q固相测定法检测循环免疫复合物均呈强阳性。在未经治疗而完全临床康复的过程中，在第33天这两种测定法检测循环免疫复合物均呈弱阳性。在第56天它们呈阴性。以该病例为原型，参考在全身性霉菌感染中可能观察到的免疫紊乱，讨论了肾脏免疫病理学和嗜酸性粒细胞反应的可能机制。
