Belovezhdov N, Altŭnkova I
Vutr Boles. 1981;20(4):38-46.
The serum levels of immunoglobulins G, A and M, C3, HBsAg and E rosettes were studied in 101 patients with various histologic forms of glomerulonephritis. The cell-conditioned immunity to antigens of glomerular basal membrane and RTE antigen were studied in 39 patients with glomerulonephritis and 53 patients with Balkan endemic nephropathy. Significantly increased serum levels of IgG, IgH and IgM were found as well as a decrease of the serum values of C3 in 40,6 per cent of the patients and circulating immune complexes in 47.5 per cent of them; 7 per cent of the patients were positive to HBsAg in serum. E-rosettes were significantly lower as compared with those of the healthy, in 46.5 per cent of the patients being under the norms. The cell conditioned immunity to GBM antigen was found in 53.8 per cent of the patients with chronic glomerulonephritis examined and to RTE antigen in 58.5 per cent of the patients with BEN. The changes found were interpreted as a disturbance in immune responses, characterized by the inhibition of T and activation of B cells, the presence of CIC, C3 reduction and high HBsAg percentage being an expression of that.
对101例患有各种组织学类型肾小球肾炎的患者的血清免疫球蛋白G、A和M、C3、乙肝表面抗原（HBsAg）及E玫瑰花结进行了研究。对39例肾小球肾炎患者和53例巴尔干地方性肾病患者的肾小球基底膜抗原及肾小管上皮细胞抗原的细胞免疫状况进行了研究。发现40.6%的患者血清免疫球蛋白G、IgH和IgM水平显著升高，47.5%的患者血清C3值降低以及循环免疫复合物出现；7%的患者血清乙肝表面抗原呈阳性。与健康人相比，46.5%的患者E玫瑰花结显著降低，低于正常范围。在接受检查的慢性肾小球肾炎患者中，53.8%的患者对肾小球基底膜抗原有细胞免疫反应，在巴尔干地方性肾病患者中，58.5%的患者对肾小管上皮细胞抗原有细胞免疫反应。所发现的这些变化被解释为免疫反应紊乱，其特征为T细胞受抑制和B细胞被激活，循环免疫复合物的存在、C3降低以及高乙肝表面抗原阳性率均是这一情况的表现。
